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Mesna Mechanism Of Action. Mechanism of Action of Mesna. Mesna is a synthetic compound that protects the bladder from the urotoxic metabolites of oxazaphosphorine derivatives eg ifosfamide cyclophosphamide by chemically interacting with them and their metabolites as a sulfhydryl donor in urine1-3 PHARMACOKINETICS. Mechanism Of Action. Mesna can be given orally.
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Ad Get Your Instant Free Coupon Now. The first step in the detoxification process is the binding of mesna to 4-hydroxyifosfamide forming a non-urotoxic 4-sulfoethylthioifosfamide. Within the kidney mesna reacts with acrolein. Mechanism Of Action. Oxidized to dimesna in the blood and is in turn reduced back to mesna in the kidney. Mesna is converted to a free thiol compound in the kidney where it binds to and inactivates acrolein and other urotoxic metabolites of ifosfamide and cyclophosphamide thereby reducing their toxic effects on the urinary tract during urinary excretion.
Mechanism Of Action.
During this detoxification there is binding of mesna to the 4-hydroxy-ifosfamide forming a nonurotoxic 4. Mesna is converted to a free thiol compound in the kidney where it binds to and inactivates acrolein and other urotoxic metabolites of ifosfamide and cyclophosphamide thereby reducing their toxic effects on the urinary tract during urinary excretion. MESNEX mesna injection for intravenous use MESNEX mesna tablets for oral use Initial US. Within the kidney mesna reacts with acrolein. The reactivated mesna works by interacting with metabolites substances produced by breakdown of a drug in the body. While the precise mechanism with which cyclophosphamide exerts its immunomodulatory effects are not completely clear several studies have suggested a few probable modes of action.
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No credit card or sign-up required to use GoodRx. However the greatest source of acrolein is cigarette smoke. Mechanism Of Action. Mesna can be given orally. MESNEX mesna injection for intravenous use MESNEX mesna tablets for oral use Initial US.
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Mechanism Of Action. Save up to 80 on Prescriptions. Mesna is an acronym for the Na salt of M ethyl E thyl S ulfonate a synthetic organo-sulfhydryl compound that conjugates and inactivates acrolein a chemically reactive metabolite of cyclophosphamide that has a toxic effect on the bladder epithelium. Mechanism Of Action. Mesna is in an inactive form in the blood stream but becomes active in the urine.
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